What is something that a person who has low self awareness can do to build resilience quizlet?

Resilience (developmental psychology)

Referred to individuals who experienced normal development in the face of remarkable childhood adversity

Resilience vs recovery

Recovery: event led to subthreshold or threshold symptoms from which the individual eventually recovered.

Resilience: ability to maintain stable equilibrium.
- Resilience does not mean that the individual does not experience distress following stressful or traumatic events.

percentage of those exposed to traumatic event that don't experience ptsd

70%

stress-resistant vs stress-resilient

individuals that never exhibit PTSD symptoms are considered "stress-resistant".

Those that show symptoms and recover quickly are "stress-resilient".

key aspects of resilience

speed of recovery and thoroughness and stability of recovery.

resilience and pathology

- Resilience (positive emotions) does not equal the absence of pathology (negative emotions).
- One can exhibit resilience in some domains but not others.
- Regulation of positive emotion is functionally distinct from regulation of negative emotion.
- Lacking a psychological disorder does not mean one is living a satisfying life.
- Amount of negative does not relate to the amount of positive

How common is resilience? (la riots, gulf war, 9/11)

1992 LA riots: fewer than three PTSD symptoms exhibited in >75% of those exposed (Hanson et al., 1995).

A majority of Gulf War veterans (> 60%) reported no psychological distress within a year of returning from war (Sutker et al., 1995).

September 11th terrorist attacks: over 40% of Manhattan residents reported no PTSD symptoms (Galea et al., 2002).

trajectories of resilience and dysfunction following potential trauma

The resilient trajectory was most common (65%)
Chronic: 12%
Recovery: 23%
Delayed: 10%

These trajectories varied by type of event (e.g., military, civilian accident, loss, etc.)

police vs non traditional responders: trajectories of PTSD risk and resilience in 9/11 responders

police
resistant/resilient: 77.8%
delayed onset: 8.5
recovering: 8.4
severe chronic: 5.3

nontraditional WTC responders
resistant/resilient: 58%
delayed onset: 6.7
recovering: 12.3
severe chronic: 9.5;
subsyndromal increasing 7.3
moderate chronice: 6.2

factors contributing to PTSD vs resilience (trajectories of PTSD risk and resilience in 9/11 responders)

Factors that contributed to PTSD trajectories:
Prior psychiatric history
Hispanic ethnicity
Severity of WTC exposure
WTC-associated medical conditions

Factors that contributed to resilient trajectory:
Higher education
Family and work support

How common is resilience?

resilience is common.
40-70%

Evidence does not support the hypothesis that PTSD symptomology is just delayed; seems to be true resilience.

Adaptive responses to stress or adversity can be promoted by ____________ potential protective factors.

strengthening

Longitudinal studies of resilience

examine resilience factors over time.
- Individuals may show maladaptive behavior short-term and resilience long-term.
- Studying populations at a single point do not allow a full understanding of resilience.

context of resilience

Resilience in one context does not always mean resilience in another context.

resilience and adversity

Level of resilience is predicted in part by level of adversity.
Perhaps those that are more resilient experienced less adversity. Studies must take into account exposure to risk.

psychological resilience factors

Positive affect
Self-efficacy
Internal locus of control

resilience factors

Genetic (e.g., serotonin transporter gene)
Developmental (e.g., stress inoculation)
Neurobiological (e.g., regulation of stress hormone responsiveness)
Psychosocial (e.g., social support)

Factors associated with risk vs resilience

intro slide 35

four waves of research on resilience

Wave 1: Description
How should resilience be defined? How should it be measured?

Wave 2: How does resilience occur?
Identify and understand processes that might lead to resilience.

Wave 3: Intervention
How can resilience be promoted?
Focus on effective parenting, training in executive function

Wave 4: Integration
Incorporates advances in genetics, biology, and statistics to create integrative models of resilience.

challenge model of resilience

Low levels of risk help to inoculate youth so that later exposure to higher levels of risk is less deleterious.

Too little risk may not prepare individuals for adversity.

at risk vs well-adapted children

Risk—known threats to development:
- Poverty and socioeconomic risk
- Maltreatment or exposure to violence
- Mass trauma events like war or disaster

Doing ok—adapting well:
- Physical or mental health
- Meeting expectations of family and society
- Meeting developmental milestones

infants and toddlers developmental tasks/milestones

Motor milestones like sitting and walking
Attachment to caregivers
Beginning to speak the language of the family and community

Early childhood developmental tasks/milestones

Following simple instructions
Listening to caregivers

childhood developmental tasks/milestones

Going to school and behaving appropriately
Learning to read and write
Getting along with other children

Adolescence and early adulthood developmental tasks/milestones

Adjusting to changing body and feelings
Completing education or training
Forming close friendships

Masten's def of resilience

The capacity of a system to adapt successfully to disturbances that threaten its stability, viability, or development.

Scalable across levels, from the smallest lowest-scale system to global systems.

Attachment system (Systems that promote resilience across the lifespan)

- Attachment is a universal process in human development.
- Early in life, attachment is with caregiver.
- Caregiver provides a "secure base" to explore the environment.
- Removal of the caregiver, even temporarily, induces extreme anxiety, fear, or panic.
- As individuals mature, attachment shifts to other people (e.g., teachers, peers) and objects (e.g., teddy bear).

Agency and mastery motivation system. (Systems that promote resilience across the lifespan)

- Motivation to adapt to the environment. Successful adaption is pleasurable.
- As the sense of self develops, so does the role of agency—"I did this", "I learned something new."

Intelligence (Systems that promote resilience across the lifespan)

- Problem solving skills, measured by traditional IQ tests, predict good adaption under adversity.
- Resilience does not require extraordinary intelligence, just good problem solving skills.
- Sometimes, less knowledge about what is going on is better
- Example: children in war don't always understand the trauma; adolescents have a better understanding for the traumatic events and may be more severely affected.

self-regulation (Systems that promote resilience across the lifespan)

- under the umbrella of "executive function"
- Working memory, attention, inhibiting a dominant response in favor of a more adaptive response, self-control.
- These skills develop as the brain matures.

Meaning making (Systems that promote resilience across the lifespan)

- Optimism, hope for the future.
- Finding something of meaning that "keeps you going" in the face of adversity.
- Help promote efforts to adapt and overcome.
- Can occur independently of organized belief systems.

Cultural traditions and religion (Systems that promote resilience across the lifespan)

- Often tied to other systems that promote resilience.
- Prayer and meditation may support self-regulation.
- Relationships with God and other spiritual figures may provide security and attachment.
- A growing area of resilience research.

mean IQ of competent, resilient, and maladaptive 20 year oldes

Competent: good adaptation, low adversity
- IQ z-score: .25

Resilient: good adaptation, high adversity
- IQ z-score: .5

Maladaptive: poor adaptation, high adversity.
- IQ z-score: -.5

The Kauai Longitudinal study studied:

- the long-term effects of adverse perinatal and early conditions on individual outcomes
- What factors allow those exposed to multiple adverse events to successfully adapt—why are some resilient?

The Kauai Longitudinal study findings

- Health status in the first 10 years of life correlated significantly with outcomes at 40 years of age.
- A big predictor of adult outcomes was maternal caregiving competence and emotional support from the family during childhood.

high-risk individuals in The Kauai Longitudinal study

- About 1/3 of the group was considered "high-risk" because of exposure to chronic poverty, birth complications, parental psychopathology, and family discord.

- Majority of "high-risk" individuals exhibited normal social and mental health outcomes in adulthood

- Poor outcomes at age 40 were associated with exposure to parental alcoholism and/or mental illness.

The Kauai Longitudinal study (Three main types of protective factors)

- Core resources: sociability, average intelligence, communication skills, attachment to parents
- Adaptive resources: emotional support from others
- External support: such as school, work, or religious affiliation

What happens in individuals that experience early life stress?

sensitization vs inoculation

sensitization

early unmanageable stress such as abuse or war may lead to "learned helplessness". Individuals show exaggerated responses to future stress, even in adulthood.

inoculation

early exposure to mild or moderate (and manageable) stress can have an "inoculating" effect and lead to reduced responses to future stress.

stress inoculation in monkeys design

Squirrel monkeys were randomized to:
- Nonstress control (NS) group
- Intermittent stress (IS) group: Separated from mother and group once a week for 10 weeks
- At weeks 35 and 50, monkeys were tested for anxiety-like behavior.

monkeys exposed to intermittent stress

- Were quicker to explore a novel environment.
- Explore novel objects more.
- Had lower cortisol at baseline and during the test in a novel environment.
Intermittent, mild stress early in life had an "inoculating" effect, such that those monkeys were more likely to explore a novel environment, suggesting less anxiety.

effect of stress inoculation on the relationship between stress and coping

- lower levels of stress promote better performance
- higher maximal performance in response to stress.
- maintenance of optimal performance at higher levels of stress
"Maintaining optimal stress exposure might prevent the development of major psychiatric dysfunction."

Developmental factors that affect resilience in children

Ability to control attention
Regulation of emotions and impulses
Ability to delay gratification
Ability to soothe self
Secure attachment to others
Empathy
Self-awareness

in the The Dunedin Longitudinal Study Self-Control was higher in

children with higher IQ and SES

The Dunedin Longitudinal Study findings

Higher levels of self-control in childhood related to
- fewer health problems in adulthood
- more wealth in adulthood
- fewer substance problems in adulthood
- positive parenting in adulthood

important bc Self-control may be more malleable than other factors

"preschool program improves cognitive control" study design background and goal

Background: Executive function skills are more predictive of success than content knowledge in children.

Goal: Teach executive function skills

the two curriculum in "preschool program improves cognitive control"

1. Tools of the mind curriculum: 40 executive function promoting activities
2. District's version of Balanced Literacy curriculum

"preschool program improves cognitive control" study findings

Tools of the mind group (gray) performed better than controls (orange) on executive function tasks.

Tasks that were more demanding of executive function correlated more strongly with standard academic measures.

Resilience across the lifespan: importance of early resilience

Resilience tends to be continuous
Those that demonstrate resilience early in life tend to continue doing so into adulthood

Resilience forms a firm base during childhood through individual, family, and environmental factors.
But, this is modifiable. There is always room for change.
For example, developing supporting relationships in early adulthood (e.g., spouse, close friends) can foster resilience in those that did not exhibit resilience early in life.

Resilience is an ongoing process.

Harvard Study of Adult Development design

Beginning around 1940, prospectively followed two socially diverse cohorts of white, male adolescents.
- 286 Harvard college sophomores: cohort of privilege
- Mortality rate half that of national males by age 50
- ~25% still living in 2011, after more than 70 years of study!

456 adolescent males from inner city Boston: cohort of social disadvantage
- Mostly children of immigrants. Brought to attention of social services agencies

Other studies of aging began later, introducing selective mortality as a bias. By starting in adolescence, those that die in adulthood are still included in the study.

6 domains of outcomes assessed in Harvard Study of Adult Development

objective physical health
Subjective physical health
Length of active life
Objective mental health
- Competence in four areas: work, relationships, play, and absence of need for psychiatric care or medication
Subjective life satisfaction
Social support

happy-well, sad-sick, and intermediate (Harvard Study of Adult Development)

Happy-well = good in all 6 areas until age 80
Sad-sick: psychosocially unhappy and physically disabled
Intermediate = in-between

Harvard Study of Adult Development results

College men at 75-80
- 26% happy-well
- 32% intermediate
- 17% sad-sick
- 25% prematurely dead

Core-City men at 65-70
- 29% happy-well
- 34% intermediate
- 14% sad-sick
- 23% prematurely dead

- for each aditional year of education the likelihood of being sad-sick or dead at 65 was reduced by .85

Harvard Study of Adult Development additional findings (physical health, marital quality, and percieved loneliness)

Physical health was as linked to social relationships as it was to cigarette smoking, obesity, and blood pressure.

Marital quality at age 50 was a stronger predictor of longevity to age 80 than was cholesterol!!

Perceived loneliness was associated with more rapid physical decline.

Consistent factors observed across studies that promotes resilience:

- Social support, especially parenting quality
- Executive function (can be trained!)

Systems that promote resilience (IMPORTANT)

Attachment system
Agency and mastery motivation system
Intelligence
- Cognitive systems associated with problem solving
Self-regulation
Meaning making
Cultural traditions and religion
- religious and spiritual systems
(Some have argued that an individual's drive to achieve these goals promotes resilience.)

gary and kenneth takeaway

How an individual perceives, responds to, and copes with external stressors can have a major impact on health.

Personality and temperamental factors influence

Perception of control and safety.

Interpretation of ambiguous situations as good or bad

Whether you seek out emotional support.

Remember, that risk factors for PTSD included maladaptive coping and response styles, personality traits, and social support.

The following _____ resilience
active coping
Personality: Self-enhancement
Emotion regulation
Adaptive self-control
Positive emotions & realistic optimism
Cognitive reappraisal & cognitive flexibility
Social support
Moral compass & religion and spirituality

promote

flexible coping (Psychosocial factors influencing resilience)

modifying behavior to met demands of a given stressor.

Active coping strategies (Psychosocial factors influencing resilience)

- Planning and problem solving
Minimize appraisal of threat, create positive statements about oneself, seek support of others.
- Exercise

Many examples of active coping strategies, categorized as approach and problem-focused.

pragmatic coping (Psychosocial factors influencing resilience)

"whatever it takes" approach that is single-minded and goal-directed.

repressive coping (Psychosocial factors influencing resilience)

Although repression is typically viewed as being negative, it is marked by automatic avoidance of threatening or negative stimuli.
- Active avoidance requires more cognitive resources and is associated with more negative outcomes than repressive coping.
Repressive coping has some long-term health costs, but is also associated with adaptation to loss.

self-enhancement (Psychosocial factors influencing resilience)

a tendency to view the self in highly favorable and even unrealistic terms.
- Associated with ability to cope well with extreme adversity
- Also associated with reduced social relationships, but those who have high self-enhancement are more likely to perceive their friends as willing to listen.
- Smaller social circle, but it may be used more effectively

Emotional regulation (Psychosocial factors influencing resilience)

Fear is normal; can be used as a guide.
Facing fears can increase self-esteem and feelings of mastery.

adaptive self-control (Psychosocial factors influencing resilience)

Includes capacity to modulate emotions and behaviors, control impulses, employ will-power and self-discipline.

positive emotions (Psychosocial factors influencing resilience)

- Daily positive emotions moderate stress reactivity and mediate stress recovery to daily stressors and bereavement (Ong et al., 2006).

- Broaden-and-build theory (Fredrickson, 2001)
- The experience of positive emotions can broaden one's actions and thoughts. This broadening then helps to build personal resources.

- In part genetic, but can be learned through Cognitive Behavioral Therapy

realistic optimism (Psychosocial factors influencing resilience)

Like pessimists: pay close attention to relevant negative information.
Unlike pessimists: do not dwell on negative information; filter out irrelevant negative information.

How to enhance realistic optimism
- Insert positive thoughts
- Refute the negative
- Have optimistic parents (genetic component)
- Pick optimistic friends

cognitive reappraisal (Psychosocial factors influencing resilience)

Ability to take negative experiences and reframe them in a positive light
Example: humor

cognitive flexibility (Psychosocial factors influencing resilience)

Ability to shift the type of strategy used to deal with stressors based on the severity, duration, context, etc.

salivary cortisol and social support in women with metastatic breast cancer

Salivary cortisol was lower in women with high support.

Interpersonal Support Evaluation List:
- Appraisal support: perceived availability of confidants
- Belonging support: availability of people to do things with
- Tangible support: availability of practical or instrumental help.

Social support (Psychosocial factors influencing resilience)

- Consistently shown to be a big predictor of positive outcomes following early life stress, trauma, and chronic stress.
- Establish and nurture a supportive social network.
- Giving, as well as receiving, social support are associated with enhanced resilience.
- Caveat: social ties can also be stressful, so the quality and type of social interaction is important in determining risk/resilience.

thomas collins iii

vietnam war

served as an Air Force piolet who engaged in bombing missions and spent more than 7 years as a prisoner of war.

"In the total sense of my life, it's probably been a good experience for me. I wouldn't erase the experience, because I got benefits out of it. I can't erase it...Frankly, it left permanently more good things in my life than it did bad things. Pain creates character."

Personal moral compass
(Psychosocial factors influencing resilience)

- Develop a set of core beliefs that you stick to.
- Altruism has been strongly related to resilience

Religion and spirituality (Psychosocial factors influencing resilience)

Associated with longevity and reduced depressive symptoms
May in part be related to social support.

Research question: In an urban sample of African-Americans, all of whom were exposed to at least one traumatic event, what psychosocial factors were associated with resilience and recovery?

slide 21 emotions and resilience

Key findings:
trauma, reislience, and recovery in a high risk african-american pop

- In the final statistical model, purpose in life emerged as a key factor associated with both resilience and recovery.
- Mastery was associated with recovery
- There were few differences between the factors involved in resilience and those involved in recovery. This suggests that some of the same mechanisms that protect individuals from developing mental disorders are likely also involved in recovery.

slide 24 emotions and resilience

...

The Child and Youth Resilience Measure (CYRM)

a measure developed with cross-cultural studies of resilience in mind.
- Developed after interviews with children and adults in 11 countries that were low-, middle-, and high-income.
- Has been validated in multiple populations, including Syrian refugee populations.
- Promising new measure to assess resilience in different populations

Cultural dimensions of resilience

The construct of resilience, as defined already, largely exists in Western, English-speaking nations.

It is clear that resilience exists across cultures, but the study of resilience is new.

Determining what factors promote resilience across different cultures is a new area of research.

Requires the validation and possibly development of new measurements for dimensions of resilience.
- What is considered a "good outcome" after a trauma may differ across cultures.
- What constitutes successful coping may differ across cultures.

Studies are relying on both qualitative and quantitative methods
- Interviews with individuals
- Developing measurements to quantify factors associated with risk/resilience in the face of stress and trauma.

type of study used to determine factors associated with resilience

longitudinal

Psychosocial factors of resilience

Active coping
Emotional regulation
Positive emotions
Realistic optimism
Cognitive reappraisal and flexibility
Social support
Personal moral compass
Religion and spirituality

Promoting resilience involves

Mobilizing powerful protective systems
Increasing assets or resources
Reducing risk

Interventions for PTSD that also promote resilience

Prolonged exposure therapy: "facing one's fears"
- Promotes active coping and emotional regulation

Cognitive processing therapy is a type of cognitive behavioral therapy that is effective in reducing symptoms of PTSD.
- Promotes active coping, cognitive reappraisal, and cognitive flexibility

the two basic forms of well-being

hedonic and eudaimonic
- Both hedonic and eudaimonic well-being are associated with reduced depression.

Hedonic

experience of pleasure
- Simpler form of well-being representing sum of an individual's positive affective experiences

eudaimonic

experience of meaning
- Results from striving toward meaning and a noble purpose. More than simple self-gratification.

Hedonic well-being was associated with a genomic profile consistent with

poorer health outcomes

-Even though both types of well-being were associated with fewer depressive symptoms, hedonic well-being was related to a genomic profile consistent with poorer health long term.

Eudaimonic well-being was associated with a genomic profile consistent with

better health outcomes.

training Active coping

can be promoted by many types of therapy.

training emotional regulation

facing fears can increase self-esteem. Learn and practice skills necessary to move through fear.

training positive emotions

In part genetic, but can be learned through cognitive behavioral therapy

training realistic optimism

Insert positive thoughts & refute negative thoughts

training Social support

Find others to communicate with.

training Personal moral compass

focus outside of oneself

Why is training so important?

Has to do with how you appraise a situation: threat or challenge?

threat vs challenge

Threat: believe that the demands of the situation exceed our personal capabilities and external resources

Challenge: believe that we have the skills, experience, and resources needed to successfully deal with the stressful situation (i.e. mastery).

Interventions enhance resilience fall into several categories

Children vs. adults
Pre-trauma ("resilience training")
Post-trauma (interventions designed to prevent PTSD)

goal of interventions enhance resilience

to promote psychosocial factors associated with resilience

Child and Family Traumatic Stress Intervention

- Four sessions designed to increase caregiver support in trauma-exposed youth
- Fewer PTSD symptoms at follow-up 3 months later

Randomized-controlled trial of Attachment and Biobehavioral Catch-Up (ABC) intervention

- Intervention focused on foster parents to improve attachment and emotional regulation in children
- Intervention group had less avoidance than control group

Stress inoculation training

- Based on observations that exposure to small, manageable stressors can "train" individuals to deal with larger stressors later in life
- Focuses on training individuals to regulate emotions, manage fears, and cope with stress.

Hardiness training

- Has been used in military to enhance coping skills and facilitate cognitive reappraisal to prepare individuals for stressful events
- Higher levels of hardiness are linked to fewer PTSD symptoms

Comprehensive Soldier Fitness program

Developed for the Army and incorporate aspects of positive psychology to promote positive emotion.

Interventions to enhance happiness and positive emotion

Perform acts of kindness
These acts of kindness must be frequent and varied

Express gratitude and optimism
Those that "counted their blessings" once a week for 6 weeks had an increase in well-being

enhance optimism
A gratitude diary (intervention) was more effective at enhancing optimism and reducing psychological pain than a food diary (control) in suicidal inpatients

Neurofeedback (Resilience training & brain activity)

Real-time fMRI paired with operant training allows people to observe and change their own brain activity in real-time!

Subjects given visual feedback while in the fMRI (Resilience training & brain activity)

- Within three sessions (4 min each), participants were able to adjust the activity of the right anterior insular cortex
- Control conditions given feedback that was not region-specific or mental imagery did not show increased activation of the right anterior insular cortex.

amygdala electrical fingerprint (Amyg-EFP)

Researchers paired EEG and fMRI to devise a model of amygdala activity, called the amygdala electrical fingerprint (Amyg-EFP).

180 military personnel undergoing military training were assigned to
- Neurofeedback: 6 sessions of neurofeedback
- Control neurofeedback
- No neurofeedback

effects of amyg-efp neurofeedback

Those in the neurofeedback group were able to use feedback to change their own amygdala reactivity.

Neurofeedback also enhanced performance in emotion-related tasks.

Physical activity

can improve psychological well being and reduce stress reactivity => it likely promotes resilience.

High impact running improves learning, increases blood levels of BDNF, dopamine, and norepinephrine (Winter et al., 2007)

Regular exercise attenuates reduction of positive mood after Trier Social Stress test (Childs and de Wit, 2014)

No studies to date looking prospectively at trauma-exposed individuals

Meditation

a form of mental training; goal is to improve attention and emotion regulation.
- Includes mindfulness meditation, mantra meditation, yoga, etc.

Mindfulness meditation

non-judgmental attention to experiences in the present moment; result is enhanced self regulation.
- Enhanced attention control
- Enhanced emotion regulation
- Increased self-awareness
All of these are associated with enhanced resilience.

methodological considerations for studies on the efficacy of mindfulness meditation

- Few studies have been replicated
- Sample sizes are low
- Few employ longitudinal designs to control for pre-existing individual differences in personality, temperament, or brain structure/function.
- Mindfulness meditation is often accompanied by changes in lifestyle/diet
- Control conditions: more recent studies are employing active control conditions, such as stress management education or relaxation training.

Brain regions involved in Attention control
(mindfulness meditation)

Anterior cingulate cortex
Striatum

Brain regions involved in Emotion regulation (mindfulness meditation)

Prefrontal areas
Limbic system
Striatum

Brain regions involved in Self-awareness (mindfulness meditation)

Insula
Medial prefrontal cortex
Posterior cingulate cortex
Precuneus

"no sustained attention differences in a longitudinal randomized trial comparing mindfulness based stress reduction versus active control" study

- One of the first studies to compare mindfulness with an active control condition.

- 8 weeks of mindfulness based stress reduction training (MSBR) vs. health enhancement program, a validated active control for mindfulness.

- Subjects were randomly assigned to MSBR or control program in a double-blind fashion. Program continued for 8 weeks.

- Sustained visual attention was assessed as the outcome measure—no effect of MSBR on sustained visual attention.

A meta-analysis of meditation vs. active control conditions determined that meditation __________ physiological markers of stress, including blood pressure, cortisol, and heart rate

reduced

A meta-analysis of mindfulness meditation demonstrated_____________negative affect and emotion regulation

improved

Meta-analysis of studies looking at anatomical differences in those that practice meditation

- Anatomical differences in prefrontal areas, areas involved in body awareness, and areas involved in emotion regulation
- Medium effect sizes
- Publication bias and methodological considerations warrant further studies.

Neuroanatomy of mindfulness meditation

The effects of meditation on the brain differ between non-meditators assigned to short-term mindfulness training and in experienced meditators.

Non-meditators (Neuroanatomy of mindfulness meditation)

- Increases white matter that connects the anterior cingulate cortex to other structures (top)
- Increased gray-matter density in hippocampus, posterior cingulate gyrus, and cerebellum

experienced mediators (Neuroanatomy of mindfulness meditation)

Altered default mode network activity in areas involved in self-monitoring and cognitive control (middle, bottom)

the following are_________
Active coping
Emotional regulation
Positive emotions
Realistic optimism
Cognitive reappraisal and flexibility
Social support
Personal moral compass
Religion and spirituality

psychosocial factors

Cognitive aspects involved in resilience:

Good problem solving
Good planning
Lower levels of denial
Broadened attentional focus
Perception of stressful events as less threatening

There is a _____________ genetic component to cognitive function and brain activation than there is to behavior.

stronger

neurobiology of Optimism and positive emotions

- In those who are optimistic in the face of stress, mesolimbic dopamine pathways may be more reward responsive and/or stress resistant.
- Functional neuroimaging studies demonstrated that the PFC and ventral striatum play a role in optimism
- Resilience in animals has been linked to specific molecular adaptations in the dopamine system.

neurobiology of facing fears and active coping

- Might be facilitated by early exposure to stressors (stress inoculation).
- Optimal functioning of fear extinction mechanisms.
- Active vs. passive coping might affect HPA axis function, although the exact relationship is unclear at the moment.
- Some suggestion that resilience is associated with increased attention to unpleasant stimuli.

neurobiology of cognitive reappraisal, positive reframing, and acceptance

Involved cognitive processes like memory suppression, memory consolidation, and top-down emotional control.

neurobiology of social competence and social support

- Brain reward circuits
- Oxytocin, a neuropeptide involved in social behavior, enhances the reward value of social attachments and also influences anxiety in animal models.

neurobiology of purpose in life, moral compass, meaning, and spirituality

Might relate to activation of brain areas involved in morality.

glucocorticoids and resilience

possible mediators of resilience. Environment can alter expression of glucocorticoid receptors; GRs can influence transcription.

Expression of FKBP5 was higher in those without PTSD after exposure to world trade center attacks

higher

the serotonin transporter promoter gene (5HTTLPR—long and short allele) and resilience

Those that had one or two copies of the short allele scored lower on the resilience scale.
- This relationship was not accounted for by childhood emotional abuse, sex, neuroticism, or ethnicity.

Studies looking at changes in gene expression in different brain regions have shown that a _____________ group of genes is changed in mice that were susceptible to stress than in those that were resilient.

different
- It is not as simple as: having gene mutation 1 = susceptible, not having that mutation = resilience

resilience is not simply the absence of maladaptive changes that occur in susceptible populations. Instead, resilience has______________

its own set of adaptive changes.

Epigenetics

Chemical changes to proteins that surround DNA that affect transcription of the gene.

FKBP5 and methylation

- The FKBP5 gene has a "risk allele" and a "protective allele"
- Methylation of these alleles as associated with childhood physical and emotional abuse
- Reduced methylation was associated with increased stress-dependent transcription and long-term dysregulation of the stress response.

the stress response that promotes resilience

low baseline levels, spikes during stress, and returns quickly to baseline
- Suggested for both HPA axis and sympathetic nervous system activation.

Dihydroepiandrosterone (DHEA)

- Released from the adrenal gland with cortisol.
- a higher DHEA:cortisol ratio is related to resilience

Norepinephrine & noradrenergic neurons

- Chronic activation of noradrenergic neurons is linked with anxiety disorders and cardiovascular problems.
- Suggests that reduced activation of noradrenergic neurons could promote resilience.

serotonin

Linked with mood regulation; acute stress affects serotonin in several brain regions linked with emotion.

dopamine

- Linked with unexpected stimuli (e.g., reward).
- facilitates fear extinction.
- Reward processing may relate to optimism.

Neuropeptide Y

- released in many of the same brain areas discussed as being important for stress and trauma.
- Helps to "put the brakes" on the sympathetic nervous system.
- Has anti-anxiety effects in rodents; may enhance cognitive function under stressful conditions.
- In the amygdala, the balance between neuropeptide Y and CRH may be important in predicting susceptibility/resilience to stress.
- Evidence for alterations in neuropeptide Y in PTSD

Plasma NPY was significantly __________ in combat-exposed veterans that did not develop PTSD.

higher

There was ______ significant difference in NPY between non-combat exposed and PTSD+ groups.

no

plasma neuropeptide y concentrations in humans exposed to military survival training: finding

During recovery:
- In non Special-Forces soldiers, plasma NPY was lower.
- In Special-Forces (aka "resilient") soldiers, plasma NPY was not different from baseline (AKA HIGH)
During acute stress:
- plasma NPY was higher than base in both groups but the difference between baseline and stress was larger than in non special forces.

Plasma NPY may promote resilience

Are there baseline differences in NPY? (plasma neuropeptide y concentrations in humans exposed to military survival training)

No. The differences emerged under stressful conditions or during recovery from stress.

There was a positive correlation between NPY and cortisol. Perhaps resilient individuals mount a significant cortisol response but are more able to turn it off.

How does neuropeptide Y (NPY) promote resilience?

- Studies using rats have determined that NPY increases extinction of fear learning.
- These effects are mediated by the amygdala. Administering NPY directly into the amygdala promotes behavioral resilience in the face of stress.

Higher levels of NPY during a stressor ________ resilience.

promote

Can NPY be given as a treatment?

Neuropeptide drug delivery is difficult—do not pass blood-brain barrier.

Some animal studies have shown positive effects of intranasal NPY administration, which bypasses the blood-brain barrier; clinical trials using intranasal delivery are underway in humans.

NPY does a lot of other stuff, so side effects are a challenge.

Determining which receptors are important in promoting resilience may lead to specific drugs to target those receptors

Social defeat stress as a model of susceptibility/resilience

Social interaction with a novel animal after social defeat has been used to determine stress susceptibility/resilience.
(Repeated social defeat by a dominant animal is a form of chronic stress.)

This effect of lower social interaction in susceptible mice was related to changes in ________________

glucocorticoid receptor expression in the hippocampus

Early maternal separation—stress inoculation & Environmental enrichment

increase the complexity of the prefrontal cortex, suggesting that activity of the prefrontal cortex is an important determinant in susceptibility/resilience to chronic stress.

nucleus accumbens and ventral tegmental area in resilience:

- animal models
- dopaminergic and important in salience (positive and negative).
- Chronic stress induces changes in the firing rates and ion channels in neurons that differ in susceptible and resilient animals.

In animal models, females are more susceptible to

the effects of chronic stress on emotion-related behaviors
- Anhedonia
- Depressive-like behavior
- Anxiety-like behavior

sex differences: stress and performance

- chronic stress improves performance on non-aversive cognitive tasks (e.g., mazes) in females
- Stress improves performance in aversive cognitive tasks (e.g., fear learning) in males.

according to Functional imaging of resilience Trauma-exposed without PTSD ("resilient") individuals exhibit

- Increased activation of the ventromedial prefrontal cortex (vmPFC) during extinction training
- Increased activation of brain regions involved in emotion regulation
- Increased connectivity between some areas of the prefrontal cortex (anterior cingulate and precentral/middle frontal gyrus)

High vagally-mediated heart rate variability

associated with resilience

Low vagally-mediated heart rate variability

associated with depression and anxiety—indicates dysfunction of the autonomic nervous system

Heart rate variability

an index of how well the cortex is controlling the brainstem and peripheral nervous system

Resilience is associated with (biology):

Altered stress reactivity
Genetic & epigenetic factors
Neuropeptide Y
Increased complexity of the prefrontal cortex in animals; increased activation of PFC in humans

possible biomarkers of resilience

NPY and Heart rate variability

In depressed individuals, the prefrontal cortex shows _____ activity.

less

In the ventral anterior cingulate cortex, depression was related to _________ activation (zif268, Arc, and cFos).

reduced

Using social defeat, mice were separated into susceptible and resilient groups and the study found that

- susceptible mice had reduced activation of the mPFC, just like the depressed humans.
- If reduced activation of the PFC is a hallmark of depression, then increasing activation of the PFC should reduce depression.

excitation of the mPFC and stressed animals

- In non-stressed animals, excitation of the mPFC did nothing.
- In stressed-susceptible mice, excitation of the mPFC reversed depressive-like behavior.
Optogenetics can be used to temporarily activate or inhibit a brain region.

What is something that a person who has low self awareness can do to build resilience?

What is something that a person who has low self-awareness can do to build resilience? Answers: a. Ask others to give advice on what the person should do.

Which of the following statements best describes one of the two dimensions of resilience?

Which of the following statements best describes one of the two dimensions of resilience? Dimension 2 involves the relative positivity of the life outcomes that stem from the use of coping strategies.

How does finding strength ethnic identity affect the academic performance of white American students quizlet?

No links have been observed in strength of ethnic identity and academic performance in White American students.

What contrast exists between Eastern and Western cultural views on optimal living quizlet?

Eastern cultures view optimal living as spiritual transcendence, while Western cultures view it as a hopeful pursuit for better life on Earth. Teachings from the Anishinaabe implicate that there are seven values, each represented by different ______.