Neurogenic bladder is bladder dysfunction (flaccid or spastic) caused by neurologic damage. Symptoms can include overflow incontinence, frequency, urgency, urge incontinence, and retention. Risk of serious complications (eg, recurrent infection, vesicoureteral reflux, autonomic dysreflexia) is high. Diagnosis involves imaging and
cystoscopy or urodynamic testing. Treatment involves catheterization or measures to trigger urination. Any condition that impairs bladder and bladder outlet afferent and efferent signaling can cause neurogenic bladder. Causes may involve the central nervous system (eg,
stroke Overview of Stroke Strokes are a
heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. Strokes can be Ischemic (80%), typically resulting... read more In flaccid
(hypotonic) neurogenic bladder, volume is large, pressure is low, and contractions are absent. It may result from peripheral nerve damage or spinal cord damage at the S2 to S4 level. After acute cord damage, initial flaccidity may be followed by long-term flaccidity or spasticity, or bladder function may improve after days, weeks, or months. In spastic bladder, volume is typically normal or small, and involuntary contractions occur. It usually results from brain damage or spinal
cord damage above T12. Precise symptoms vary by site and severity of the lesion. Bladder contraction and external urinary sphincter relaxation are typically uncoordinated (detrusor-sphincter dyssynergia). Mixed patterns (flaccid and spastic bladder) may be caused by many disorders, including
syphilis Syphilis
Syphilis is caused by the spirochete Treponema pallidum and is characterized by 3 sequential clinical, symptomatic stages separated by periods of asymptomatic latent infection. Common... read more Patients with spastic bladder may have frequency, nocturia, and spastic paralysis with sensory deficits; most have intermittent bladder contractions causing urine leakage and, unless they lack sensation, urgency. In patients
with detrusor-sphincter dyssynergia, sphincter spasm during voiding may prevent complete bladder emptying. Common complications include recurrent
urinary tract infections
Introduction to Urinary Tract Infections (UTIs) Urinary tract infections (UTIs) can be divided into upper tract infections, which involve the kidneys ( pyelonephritis), and lower tract infections, which involve the bladder ( cystitis), urethra... read more and
urinary calculi Urinary Calculi
Urinary calculi are solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection. Diagnosis is based on... read more . Hydronephrosis with
vesicoureteral reflux
Vesicoureteral Reflux (VUR) Vesicoureteral reflux is retrograde passage of urine from the bladder back into the ureter and sometimes also into the renal collecting system, depending on severity. Reflux predisposes to urinary... read more may occur because the large urine volume puts
pressure on the vesicoureteral junction, causing dysfunction with reflux and, in severe cases, nephropathy. Patients with high thoracic or cervical spinal cord lesions are at risk of autonomic dysreflexia (a life-threatening syndrome of malignant hypertension, bradycardia or tachycardia, headache, piloerection, and sweating due to unregulated sympathetic hyperactivity). This disorder may be triggered by acute bladder distention (due to
urinary retention Urinary
Retention Urinary retention is incomplete emptying of the bladder or cessation of urination. Urinary retention may be Acute Chronic Causes include impaired bladder contractility, bladder outlet obstruction... read more ) or bowel distention (due to constipation or fecal impaction). Postvoid residual volume Renal ultrasonography Symptoms and Signs
Serum creatinine
Usually cystography, cystoscopy, and cystometrography with urodynamic testing
Diagnosis is suspected clinically. Usually, postvoid residual volume is measured, renal ultrasonography is done to detect hydronephrosis, and serum creatinine is measured to assess renal function.
Further studies are often not done in patients who are not able to self-catheterize or ask to go to the bathroom (eg, severely debilitated older or post-stroke patients).
In patients with hydronephrosis or nephropathy who are not severely debilitated, cystography, cystoscopy, and cystometrography with urodynamic testing are usually recommended and may guide further therapy.
Cystography is used to evaluate bladder capacity and detect ureteral reflux.
Cystoscopy is used to evaluate duration and severity of retention (by detecting the degree of bladder trabeculations) and to check for bladder outlet obstruction.
Cystometrography can determine whether bladder volume and pressure are high or low; if done during the recovery phase of flaccid bladder after spinal cord injury, it can help evaluate detrusor functional capacity and predict rehabilitation prospects (see Testing: "In cystometrography..." Testing ).
Urodynamic testing Testing of voiding flow rates with sphincter electromyography can show whether bladder contraction and sphincter relaxation are coordinated.
Catheterization
Increased fluid intake
Drugs
Surgery if conservative measures fail
Prognosis is good if the disorder is diagnosed and treated before kidneys are damaged.
Specific treatment involves catheterization Bladder Catheterization Bladder catheterization is used to do the following: Obtain urine for examination Measure residual urine volume Relieve urinary retention or incontinence Deliver radiopaque contrast agents or... read more or measures to trigger urination. Intermittent catheterization is preferred to continuous catheterization whenever possible. General treatment includes renal function monitoring, control of urinary tract infections Introduction to Urinary Tract Infections (UTIs) Urinary tract infections (UTIs) can be divided into upper tract infections, which involve the kidneys ( pyelonephritis), and lower tract infections, which involve the bladder ( cystitis), urethra... read more (UTIs), high fluid intake to decrease risk of UTIs and urinary calculi Urinary Calculi Urinary calculi are solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection. Diagnosis is based on... read more (although this measure may exacerbate incontinence), early ambulation, frequent changes of position, and dietary calcium restriction to inhibit calculus formation.
For flaccid bladder, especially if the cause is an acute spinal cord injury, immediate continuous or intermittent catheterization is needed. Intermittent self-catheterization is preferable to indwelling urethral catheterization, which has a high risk of recurrent UTIs and, in men, a high risk of urethritis Urethritis Bacterial urinary tract infections (UTIs) can involve the urethra, prostate, bladder, or kidneys. Symptoms may be absent or include urinary frequency, urgency, dysuria, lower abdominal pain... read more , periurethritis, prostatic abscesses, and urethral fistulas. Suprapubic catheterization Suprapubic catheterization Bladder catheterization is used to do the following: Obtain urine for examination Measure residual urine volume Relieve urinary retention or incontinence Deliver radiopaque contrast agents or... read more may be used if patients cannot self-catheterize.
Surgery is a last resort. It is usually indicated if patients have had or are at risk of severe acute or chronic sequelae or if social circumstances, spasticity, or quadriplegia prevents use of continuous or intermittent bladder drainage. Sphincterotomy (for men) converts the bladder into an open draining conduit. Sacral (S3 and S4) rhizotomy converts a spastic into a flaccid bladder. Urinary diversion may involve an ileal conduit or ureterostomy.
An artificial, mechanically controlled urinary sphincter, surgically inserted, is an option for patients who have adequate bladder capacity, good bladder emptying, and upper extremity motor skills and who can comply with instructions for use of the device; if patients do not comply, life-threatening situations (eg, renal failure, urosepsis) can result.
Damage to the neural pathways that control voiding can render the bladder too flaccid or spastic.
Flaccid bladder tends to cause overflow incompetence.
Spastic bladder tends to cause frequency, urge incontinence and, particularly with detrusor-sphincter dyssynergia, retention.
Measure postvoid residual volume, do renal ultrasonography and serum creatinine measurement, and in many patients, do cystography, cystoscopy, and cystometrography with urodynamic testing.
Treatment for flaccid bladder includes increased fluid intake and intermittent self-catheterization.
Treatment for spastic bladder may include measures to trigger urination and/or measures used to treat urge incontinence (including drugs).
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